Salutary Effects of Androstenediol on Cardiac Function and Splanchnic Perfusion following Trauma-hemorrhage
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چکیده
Please address correspondence, proofs and reprints to: Dr. Irshad H. Chaudry Center for Surgical Research University of Alabama at Birmingham 1670 University Boulevard Volker Hall, Room G094 Birmingham Alabama 35294-0019 Phone: (205) 975-2195 Fax: (205) 975-9719 E-mail: [email protected] Articles in PresS. Am J Physiol Regul Integr Comp Physiol (April 29, 2004). 10.1152/ajpregu.00214.2004
منابع مشابه
Salutary effects of androstenediol on cardiac function and splanchnic perfusion after trauma-hemorrhage.
Recent studies have shown that dehydroepiandrosterone (DHEA) administration after trauma-hemorrhage (T-H) improves cardiovascular function and decreases cytokine production in male animals. Although androstenediol, one of the metabolites of DHEA, is reported to have estrogen-like activity, it remains unknown whether androstenediol per se has any salutary effects on cytokines and cardiovascular ...
متن کاملMechanism of salutary effects of androstenediol on hepatic function after trauma-hemorrhage: role of endothelial and inducible nitric oxide synthase.
Recent studies have shown that administration of dehydroepiandrosterone (DHEA) after trauma-hemorrhage (T-H) improves cardiovascular and hepatic function in male animals. Although androstenediol, one of the DHEA metabolites, has been recently reported to produce salutary effects on cardiac function and splanchnic perfusion after T-H, it remains unknown whether androstenediol per se has any salu...
متن کاملMechanism of Salutary Effects of Androstenediol on Hepatic Function following Trauma-hemorrhage: the Role of Endothelial and Inducible Nitric Oxide Synthase
Please address correspondence, proofs and reprints to: Dr. Irshad H. Chaudry Center for Surgical Research University of Alabama at Birmingham 1670 University Boulevard Volker Hall, Room G094 Birmingham Alabama 35294-0019 Phone: (205) 975-9710 Fax: (205) 975-9715 E-mail: [email protected] Articles in PresS. Am J Physiol Gastrointest Liver Physiol (September 23, 2004). doi:10.1152/ajpgi....
متن کاملGender dimorphic tissue perfusion response after acute hemorrhage and resuscitation: role of vascular endothelial cell function.
Proestrous female rodents are protected from the deleterious effects of trauma-hemorrhage that are observed in males. We hypothesized that the gender dimorphic outcome after trauma-hemorrhage might be related to gender differences in endothelial function and organ perfusion under such conditions. Male and cycle-matched proestrous female Sprague-Dawley rats underwent a midline laparotomy, hemorr...
متن کاملMechanisms of the salutary effects of dehydroepiandrosterone after trauma-hemorrhage: direct or indirect effects on cardiac and hepatocellular functions?
BACKGROUND Dehydroepiandrosterone (DHEA) is the most abundant adrenal hormone in man and has been shown to improve immune functions after trauma-hemorrhage. However, it remains unknown whether this agent has any salutary effects on the depressed organ functions under such conditions. HYPOTHESIS Administration of DHEA after trauma-hemorrhage attenuates depressed cardiac and hepatocellular func...
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تاریخ انتشار 2004